The Relationship between Recurrent Aphthous Stomatitis and Metabolic Syndrome

Tahmoores Abdollahian, Solmaz Pourzare Mehrbani, Paria Motahari

Abstract


Metabolic syndrome or X syndrome includes a group of metabolic and non-metabolic disorders, that increase the risk of some disease. This study aimed to determine the prevalence of metabolic syndrome in healthy subjects and patients with recurrent aphthous stomatitis (RAS) was conducted. In this cross-sectional study 33 patients with recurrent aphthous stomatitis which were referred to Department of Oral Medicine of Tabriz dental school were studied. The inclusion criteria included consent to participates in the study, lack of underlying disease associated with RAS such as Behcet’s syndrome and lack of systemic diseases. RAS patients were examined in terms of risk of the metabolic syndrome and 33 age and sex matched healthy individuals were selected and examined in terms of risk of metabolic syndrome. Data samples from check list contain demographic and laboratory findings were collected. Results showed that the prevalence of metabolic syndrome in patients with RAS (21.2%) was significantly higher than in healthy people (9.1%). (p<0.05) Female percentage of RAS patients with metabolic syndrome were 71.4 and Male percentage of RAS patients with metabolic syndrome were 28.6. Given the high prevalence of metabolic syndrome in patients with RAS, this syndrome can be considered as a risk factor for RAS.


Keywords


Recurrent Aphthous Stomatitis, Metabolic Syndrome, Blood Pressure

Full Text:

PDF

References


Chattopadhyay A, Shetty KV. Recurrent aphthous stomatitis. Otolaryngologic clinics of North America. 2011;44(1):79-88.

Kumar M, Ananthakrishnan V, Goturu J. Etiology and pathophysiology of recurrent aphthous stomatitis: a review. Int J Cur Res Rev. 2014;6(10):16.

McNeill AM, Rosamond WD, Girman CJ, Golden SH, Schmidt MI, East HE, et al. The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in communities study. Diabetes care. 2005;28(2):385-90.

Shiwaku K, Nogi A, Kitajima K, Anuurad E, Enkhmaa B, Yamasaki M, et al. Prevalence of the metabolic syndrome using the modified ATP III definitions for workers in Japan, Korea and Mongolia. Journal of occupational health. 2005;47(2):126-35.

Rashidi AA, Parastouei K, Aarabi MH, Taghadosi M, Khandan A . Prevalence of metabolic syndrome among students of Kashan University of Medical Sciences in 2008. Feyz. 2010; 13( 4):307-312.

Azizi F, Salehi P, Etemadi A, Zahedi-Asl S. Prevalence of metabolic syndrome in an urban population: Tehran lipid and Glucose Study. Diabetes Res Clin Pract. 2003; 61(1):29-37.

Han TS, Sattar N, Williams K, Gonzalez-Villalpando C, Lean ME, Haffner SM. Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study. Diabetes care. 2002;25(11):2016-21.

Lee YH, Pratley RE. The evolving role of inflammation in obesity and the metabolic syndrome. Current diabetes reports. 2005;5(1):70-5.

Vahedi M, Abdolahzadeh S, Abdossamadi H. Evaluation of serum levels of interleukin 6 and 8 in patients with recurrent aphthous ulcers. Journal of Dental Medicine, Shiraz University of Medical Sciences. 2008;9(4):332.

Sun A, Chia JS, Chang YF, Chiang CP. Levamisole and Chinese medicinal herbs can modulate the serum interleukin-6 level in patients with recurrent aphthous ulcerations. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2003;32(4):206-14.

Yamamoto T, Yoneda K, Ueta E, Osaki T. Serum cytokines, interleukin-2 receptor, and soluble intercellular adhesion molecule-1 in oral disorders. Oral surgery, oral medicine, and oral pathology. 1994;78(6):727-35.

Krishnamoorthy B, Garlapati K. Lipid profile and metabolic syndrome status in patients with oral lichen planus, oral lichenoid reaction and healthy individuals attending a dental college in northern India - a descriptive study. Journal of clinical and diagnostic research. 2014;8(11):92-5.

Baykal L, Arıca DA, Yaylı S, Örem A, Bahadır S, Altun E, Yaman H. Prevalence of Metabolic Syndrome in Patients with Mucosal Lichen Planus: A Case-Control Study. Am J Clin Dermatol. 2015;16(5):439-45.

Padhi T, Garima. Metabolic syndrome and skin: Psoriasis and beyond. Indian J Dermatol. 2013; 58:299-305.

Yen AM, Chen SL, Chiu SY, et al. Association between metabolic syndrome and oral pre-malignancy: a community-and population-based study. Oral Oncol. 2011;47:625–30.

Chang-Cheng Chang C.C, Lin M.S, Chen Y.T, Tu L.T, Jane S.W, Chen M.Y. Metabolic syndrome and health-related behaviours associated with pre-oral cancerous lesions among adults aged 20–80 years in Yunlin County, Taiwan: a cross-sectional study. BMJ Open. 2015;5:e008788.

Gúlcan E , Serum lipid levels in patients with minor recurrent aphthous ulcers, American Journal of Dentistry. 2015: 28(3);133-136.

Al-Ahmad BEM, Abdul Jabbar, Shaaban N, Kashmoola MA. The effect of high cholesterol level on recurrent rate of oral ulcer. J Dent Oral Health. 2018:4(2); 1-6.

Takci Z, Karadag AS, Ertugrul DT, Bilgili SG. Elevated insulin resistance in patients with recurrent aphthous stomatitis. Clin Oral Investig. 2015:19(6); 1193-7.




DOI: http://dx.doi.org/10.7575/aiac.abcmed.v.8n.4p.8

Refbacks

  • There are currently no refbacks.




Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

2013-2020 (CC-BY) Australian International Academic Centre PTY.LTD.

Advances in Bioscience and Clinical Medicine