Neuroprotective Effects of Citicoline in Diffuse Axonal Injuries

Firooz Salehpou, Ghaffar Shokouhi, Moslem Shakeri, Mohammad Shimia, Atta Mahdkhah, Ali Baradaran, Mohammad Taghi Imani, arhad Mirzaee, Aydin Kazempour Azar, Amir Mohammad Bazzazi, Hadi Mohammad Khanli


Citicoline is a neuroprotective agent and fundamental item of phospholipid biosynthesis in cell walls. In this study, we aimed at examining the effect of citicoline in patients suffering from traumatic brain injury with Glasgow Coma Score (GCS) ≤ 8, and diffuse axonal injury (DAI) diagnosis. Efficacy of citicoline was evaluated by measurement of malondialdehyde (MDA) plasma levels as a marker of oxidative stress. Forty patients were randomly divided into two groups of cases (treated with citicoline) and controls (treated without citicoline). The duration of study was 15 days and 13 blood samplings were performed on the 1st, 10th and12th days of admission to evaluate the plasma levels of MDA.
Citicoline was administered intravenously with dosage of 500mg/6h. In the control group, the mean plasma levels of MDA were 2.54±0.83, 2.43±0.79 and 2.39±0.97 ng/dL in first, second, and third blood samplings, respectively (P=0.85). In the case group, the mean plasma levels of MDA were 2.46±1.08, 1.99± 0.81 and 1.60±0.6 ng/dL in first, second and third blood samplings, respectively (P=0.01). The mean total plasma levels of MDA were comparable in the case (2.64±1.08 ng/dL) and control groups (2.54±0.83 ng/dL) (P=0.78). The results of this study suggest that citicoline is an effective neuroprotective agent which might be used in order to reduce MDA levels.

Keywords: Citicoline; malondialdehyde; traumatic brain injury

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