Effect of Different Doses of Granisetron on Preventing Postoperative Shivering in Patients undergoing Septorhinoplasty under General Anesthesia

Reza Movassaghi Gargari, Hassan Mohammadi Poor Anvari

Abstract


Background: Postoperative shivering is a frequent complication in recovery room after general anesthesia and has been reported in 40-70% of patients undergoing surgery. Postoperative shivering might cause hypoxemia, increase in oxygen consumption, a linear increase in carbon dioxide production, lactic acidosis, and increased intraocular pressure and intracranial pressure. The aim of this study was to compare the effects of different doses of granisetron on preventing postoperative shivering in patients undergoing septorhinoplasty under general anesthesia. Methods: 90 patients aged 18-60 years old with grades Ι or ΙΙ of American Society of Anesthesiologists (ASA) physicals classification were allocated to the study. The first group (G1) received Granisetron 1mg Intra Venous (IV) before anesthesia induction; the second group (G2) received 3mg Granisetron IV before anesthesia induction and the last group, the control group, received Normal Saline (NS). Three groups were matched regarding age, gender, weight and duration of surgery. Shivering grade and time of operation were recorded in the recovery room. Results: 90 patients scheduled for septorhinoplasty, including 54 men and 36 women, were enrolled to the study.  The mean age of the patients was 28.53 ± 8.62 (18-60) years. The number of the patients suffering from shivering in the recovery room was significantly less in group G2 rather than control group (P=0.006) and also need to therapy was significantly less in this group (G2) compared with the control group (P=0.002). 

Conclusion: Prophylactic use of granisetron (3mg, IV) can be effective in preventing postoperative shivering following septorhinoplasty. 


Keywords


Granisetron; Shivering; General Anesthesia;

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References


Abdollahi MH, Forouzannia SK, Bagherinasab M, Barzegar K, Fekri A, Sarebanhassanabadi M, Entezari A. The effect of ondansetron and meperedin on preventing shivering after off-pump coronary artery bypass graft. Acta Med Iran 2012;50(6): 395-398

Witte JD, Sessler DI. Perioperative shivering: physiology and pharmacology. Anesthesiology 2002;96:467-484

Taqi A. Can you stop shivering doctor? J Anesth Pain & Care 2013;17(1):4-5

Dal D, Kose A, Honca M, Akinci SB, Basgul E, Aypar U. Efficacy of prophylactic ketamine in preventing postoperative shivering. Br J Anesth 2005;95:189-192.

Buggy DJ, Crossley AWA. Thermoregulation, mild perioperative hypothermia and post-anesthetic shivering. Br J Anesth 2000;84:615-628

Eydi M, Golzari SE, Aghamohammadi D, Kolahdouzan K, Safari S, Ostadi Z. Postoperative Management of Shivering: A Comparison of Pethidine vs. Ketamine. Anesth Pain Med. 2014; 4(2):e15499.

Iqbal A, Ahmed, A Rudra, Wankhede RG, Sengupta S, Das T, Roy D. Prophylactic Granisetron Vs Pethidine for the Prevention of Postoperative Shivering: A Randomized Control Trial. Indian Journal Anesth 2009;53(3):330-334

Fuji Y, Tanka H, Tokooya H. Granisetron prevents nausea and vomiting during spinal anesthesia for caesarean section. Acta Anansthesiol Scand 1998;42:312-315

Biwas BN, Rudka A. Comparison of granisetron and granisetron plus dexamethasone for prevention of prospective nausea and vomiting after laparoscopic cholecystectomy. Acta Anasthesiol Scand 2003;47:79-83

Katyal S, Tewari A. Shivering: anesthetic considerations. J Anesth Clin Pharmacol 2002;18:363-376

Eldaba AA, Amir YM. Premedication with granisetron reduces shivering during spinal anesthesia in children. Anesth Intensive Care 2012;40(1):150-153

Sajedi P, Yaraghi A, Moseli HA. Efficacy of granisetron in preventing postanesthetic shivering. Acta Anesthesiol Taiwan 2008;46(4):166-170

Generali J, Cada D. Off-label drug uses granisetron: Postanesthetic shivering. Hospital Pharmacy 2007;42(5):424-427

Mahmud AM, Zaki MA. Granisetron Reduces shivering after general anesthesia. Med J Cairo Univer 2013;81(2):127-131




DOI: http://dx.doi.org/10.7575/aiac.abcmed.17.05.02.04

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